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	<title>Comments for The Official PLoS Blog</title>
	
	<link>http://blogs.plos.org/plos</link>
	<description>Diverse Perspectives on Science and Medicine</description>
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		<title>Comment on Evidence-based medicine under attack by toni bark</title>
		<link>http://feeds.plos.org/~r/plos/blogs/plosComments/~3/oXwv_KCgM9w/</link>
		<dc:creator>toni bark</dc:creator>
		<pubDate>Mon, 23 Jan 2012 16:06:36 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.plos.org/plos/?p=99#comment-3435</guid>
		<description>The biggest issue I have with EBM is showing something achieves a desired result without taking into consideration the totality of the situation. Acid blockers, a great example, do they reduce irritation of the esophagus, yes but at what price? the reflux is not reduced, in fact increased and the side effects of having an abnormal ph of the stomach are great. Statins, do they reduce the total ldl number, yes but in many cases by effecting the liver in such a way that IR is increased and the density profile is worse. The price to pay for the single desired result is not looked at in most EBM. We need to start looking at patients as complex adaptive systems and take into consideration how the complex system adapts to the treatment being studied.</description>
		<content:encoded><![CDATA[<p>The biggest issue I have with EBM is showing something achieves a desired result without taking into consideration the totality of the situation. Acid blockers, a great example, do they reduce irritation of the esophagus, yes but at what price? the reflux is not reduced, in fact increased and the side effects of having an abnormal ph of the stomach are great. Statins, do they reduce the total ldl number, yes but in many cases by effecting the liver in such a way that IR is increased and the density profile is worse. The price to pay for the single desired result is not looked at in most EBM. We need to start looking at patients as complex adaptive systems and take into consideration how the complex system adapts to the treatment being studied.</p>
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	<feedburner:origLink>http://blogs.plos.org/plos/2006/09/evidence-based-medicine-under-attack/#comment-3435</feedburner:origLink></item>
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		<title>Comment on Evidence-based medicine under attack by The Bishop of Manderville</title>
		<link>http://feeds.plos.org/~r/plos/blogs/plosComments/~3/cYRVtceWEaA/</link>
		<dc:creator>The Bishop of Manderville</dc:creator>
		<pubDate>Sun, 25 Dec 2011 17:51:58 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.plos.org/plos/?p=99#comment-3369</guid>
		<description>Apparently, this author can't even wrap his mind around the possible fact that there may be some serious toxicities to the dominance of EBM.   

The author's apparent first order of business is to dismiss this attack on EBM because of its language.   Apparently words such as "hegemony" are too complex and terms such as "intention-to-treat analysis,"  and "logistic regression -derived odds ratio"  are straightforward.   Come now.

Next, the author presents the rather obvious rationale for EBM.   If well constructed studies clearly show a treatment to be ineffective or harmful why would anyone choose the treatment?  Come now.   A 6th grader could figure this out.   It is not EBM that is being attacked per se.  It is the dominance of EBM that is being criticized.  The author completely misses this point and consequently, instead of actually learning something goes into "counterattack mode".

The dominance of EBM is clearly having widespread toxicities on the production of new knowledge and creative thought and secondarily, promotes a myopic biomedical approach to certain problems.  For example, how many dozens of new antidepressants does EBM have to discover before we realize that depression is a much deeper problem, linked to our social and cultural toxicities, than to 5 of 9 symptoms for 2 weeks.   Come now.</description>
		<content:encoded><![CDATA[<p>Apparently, this author can&#8217;t even wrap his mind around the possible fact that there may be some serious toxicities to the dominance of EBM.   </p>
<p>The author&#8217;s apparent first order of business is to dismiss this attack on EBM because of its language.   Apparently words such as &#8220;hegemony&#8221; are too complex and terms such as &#8220;intention-to-treat analysis,&#8221;  and &#8220;logistic regression -derived odds ratio&#8221;  are straightforward.   Come now.</p>
<p>Next, the author presents the rather obvious rationale for EBM.   If well constructed studies clearly show a treatment to be ineffective or harmful why would anyone choose the treatment?  Come now.   A 6th grader could figure this out.   It is not EBM that is being attacked per se.  It is the dominance of EBM that is being criticized.  The author completely misses this point and consequently, instead of actually learning something goes into &#8220;counterattack mode&#8221;.</p>
<p>The dominance of EBM is clearly having widespread toxicities on the production of new knowledge and creative thought and secondarily, promotes a myopic biomedical approach to certain problems.  For example, how many dozens of new antidepressants does EBM have to discover before we realize that depression is a much deeper problem, linked to our social and cultural toxicities, than to 5 of 9 symptoms for 2 weeks.   Come now.</p>
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		<title>Comment on Voluntary Medical Male Circumcision (VMMC) – a cost-effective HIV prevention measure in eastern and southern Africa: a UNAIDS and PEPFAR collection by Mathias Masem, M.D.</title>
		<link>http://feeds.plos.org/~r/plos/blogs/plosComments/~3/gUTH__CGMBM/</link>
		<dc:creator>Mathias Masem, M.D.</dc:creator>
		<pubDate>Sun, 25 Dec 2011 02:00:52 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.plos.org/plos/?p=2773#comment-3367</guid>
		<description>The hypothesis that VMMC is actually effective in preventing HIV is based on several studies with very questionable results.  This hardly seems a prudent way to determine a major health policy. Nonetheless, even if VMMC had an effect in reducing HIV, is it worth the human and monitary cost?

The article on the Kenyan study cites a 1% complication rate.  Could it be said that the approximately 100 men with reported complications out of the approximately 10,000 men in the study would otherwise have contracted HIV?

MC is the only routine surgical procedure which is done for prophylactic reasons and not to treat pathology. The logistics of mounting a massive VMMC campaign in Africa are daunting.  This is not to mention the prospect of  the cited "assembly lines" and the empowerment of paraprofessionals to do surgery which would simply invite complications and provide incentive for unscrupulous individuals to victimize the male population for financial gain.

It seems imprudent to spend billions of public health dollars on an intervention involving a harmful surgical procedure with a significant complication rate, with questionable effectiveness.  It seems even more imprudent to divert scarce resources from other interventions including hygiene, condoms, education, and an HIV vaccine.



 



,</description>
		<content:encoded><![CDATA[<p>The hypothesis that VMMC is actually effective in preventing HIV is based on several studies with very questionable results.  This hardly seems a prudent way to determine a major health policy. Nonetheless, even if VMMC had an effect in reducing HIV, is it worth the human and monitary cost?</p>
<p>The article on the Kenyan study cites a 1% complication rate.  Could it be said that the approximately 100 men with reported complications out of the approximately 10,000 men in the study would otherwise have contracted HIV?</p>
<p>MC is the only routine surgical procedure which is done for prophylactic reasons and not to treat pathology. The logistics of mounting a massive VMMC campaign in Africa are daunting.  This is not to mention the prospect of  the cited &#8220;assembly lines&#8221; and the empowerment of paraprofessionals to do surgery which would simply invite complications and provide incentive for unscrupulous individuals to victimize the male population for financial gain.</p>
<p>It seems imprudent to spend billions of public health dollars on an intervention involving a harmful surgical procedure with a significant complication rate, with questionable effectiveness.  It seems even more imprudent to divert scarce resources from other interventions including hygiene, condoms, education, and an HIV vaccine.</p>
<p>,</p>
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		<title>Comment on Voluntary Medical Male Circumcision (VMMC) – a cost-effective HIV prevention measure in eastern and southern Africa: a UNAIDS and PEPFAR collection by John V. Geisheker, J.D., LL.M.</title>
		<link>http://feeds.plos.org/~r/plos/blogs/plosComments/~3/MusC1M1e8nY/</link>
		<dc:creator>John V. Geisheker, J.D., LL.M.</dc:creator>
		<pubDate>Thu, 15 Dec 2011 18:36:06 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.plos.org/plos/?p=2773#comment-3299</guid>
		<description>Even if one were to accept the conclusions of the African RCT’s, (and the statistical sleights-of-hand suggest wariness), that does not necessarily make VMMC good epidemiology. There is a melancholy list of contraindications which transcend computer modeling:

•	Risk avoidance by circumcised men who will now feel ‘invulnerable’ and will avoid condoms. This is especially true where the men feel a western ‘surgery’ confers extra immunity over tribal rituals.

•	That trend, already identified, endangers millions of women and may even worsen the epidemic.

•	VMMC will inevitably ensnare minors. In no world culture is MC entirely voluntary, that is, for consenting adults only. VMMC has always been a stalking horse for unconsented infant circumcision.

•	In cultures which value displays of masculine bravery, MC will veer toward the gruesome rather than stay within clinical standards. South Korea is an example of this phenomenon.

•	The initial clinical standards will soon decline in village settings where even clean water is a luxury. Indeed one of the unaccounted for factors in the RCT’s is the vector of iatogenic transmission via contaminated medical equipment.

•	Once introduced, MC will prove difficult to eradicate when an HIV immunization is eventually found, as genital mutilations are self-replicating and self-sustaining. They need no reason other than, “They did it to me.” The Cut always become Cutters.

•	An AIDS vaccine has already been found -in HAART- which reduces infection rates to near zero between discordant partners.  HAART will surely prove less expensive than huge VMMC campaigns in the long run.

•	VMMC will firmly plant the notion that amputations are the preferred solution to disease processes, a giant step backwards in both human rights and medical science. 

•	VMMC will slow attempts to control FGC, female genital cutting, and may introduce FGC, unbidden, where it is now unknown. Blaming female mucosal tissue is a small additional step after VMMC.

•	VMMC may pit tribe against tribe. In Kenya, the Luo (the tribe of Barack Obama’s father), do not engage in MC. But the Kikuyu, who blame the Luo for HIV /AIDS at the urging of researchers, do so. This has led to kidnapping and forced MC of the Luo. This will surely escalate in multiple cultures across Africa, creating a fertile ground for regional conflicts.

John V. Geisheker, J.D., LL.M.
Executive Director,
General Counsel,
DoctorsOpposingCircumcision.org
Seattle, Washington, USA</description>
		<content:encoded><![CDATA[<p>Even if one were to accept the conclusions of the African RCT’s, (and the statistical sleights-of-hand suggest wariness), that does not necessarily make VMMC good epidemiology. There is a melancholy list of contraindications which transcend computer modeling:</p>
<p>•	Risk avoidance by circumcised men who will now feel ‘invulnerable’ and will avoid condoms. This is especially true where the men feel a western ‘surgery’ confers extra immunity over tribal rituals.</p>
<p>•	That trend, already identified, endangers millions of women and may even worsen the epidemic.</p>
<p>•	VMMC will inevitably ensnare minors. In no world culture is MC entirely voluntary, that is, for consenting adults only. VMMC has always been a stalking horse for unconsented infant circumcision.</p>
<p>•	In cultures which value displays of masculine bravery, MC will veer toward the gruesome rather than stay within clinical standards. South Korea is an example of this phenomenon.</p>
<p>•	The initial clinical standards will soon decline in village settings where even clean water is a luxury. Indeed one of the unaccounted for factors in the RCT’s is the vector of iatogenic transmission via contaminated medical equipment.</p>
<p>•	Once introduced, MC will prove difficult to eradicate when an HIV immunization is eventually found, as genital mutilations are self-replicating and self-sustaining. They need no reason other than, “They did it to me.” The Cut always become Cutters.</p>
<p>•	An AIDS vaccine has already been found -in HAART- which reduces infection rates to near zero between discordant partners.  HAART will surely prove less expensive than huge VMMC campaigns in the long run.</p>
<p>•	VMMC will firmly plant the notion that amputations are the preferred solution to disease processes, a giant step backwards in both human rights and medical science. </p>
<p>•	VMMC will slow attempts to control FGC, female genital cutting, and may introduce FGC, unbidden, where it is now unknown. Blaming female mucosal tissue is a small additional step after VMMC.</p>
<p>•	VMMC may pit tribe against tribe. In Kenya, the Luo (the tribe of Barack Obama’s father), do not engage in MC. But the Kikuyu, who blame the Luo for HIV /AIDS at the urging of researchers, do so. This has led to kidnapping and forced MC of the Luo. This will surely escalate in multiple cultures across Africa, creating a fertile ground for regional conflicts.</p>
<p>John V. Geisheker, J.D., LL.M.<br />
Executive Director,<br />
General Counsel,<br />
DoctorsOpposingCircumcision.org<br />
Seattle, Washington, USA</p>
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		<title>Comment on New Hope – The New Platform for the PLoS Journal Websites by News You Need to Start the Week | Against-the-Grain.com</title>
		<link>http://feeds.plos.org/~r/plos/blogs/plosComments/~3/AH9hrWmYHZ4/</link>
		<dc:creator>News You Need to Start the Week | Against-the-Grain.com</dc:creator>
		<pubDate>Mon, 12 Dec 2011 14:18:06 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.plos.org/plos/?p=2735#comment-3271</guid>
		<description>[...] New Hope – The New Platform for the PLoS Journal Websites [...]</description>
		<content:encoded><![CDATA[<p>[...] New Hope – The New Platform for the PLoS Journal Websites [...]</p>
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		<title>Comment on Voluntary Medical Male Circumcision (VMMC) – a cost-effective HIV prevention measure in eastern and southern Africa: a UNAIDS and PEPFAR collection by Hugh7</title>
		<link>http://feeds.plos.org/~r/plos/blogs/plosComments/~3/DkLO7P_uzd8/</link>
		<dc:creator>Hugh7</dc:creator>
		<pubDate>Fri, 09 Dec 2011 22:17:03 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.plos.org/plos/?p=2773#comment-3251</guid>
		<description>This pile of material reminds me of the TranAmerica building standing upside down. It all rests on the tiny point of  73 out of 5,400 circumcised men who didn't get HIV in less than two years, who MIGHT have if they hadn't been circumcised, while 64 circumcised men DID get it. 

A new review in the Australian Journal of Law and Medicine unravels some of the many reasons that may not be cause and effect:
researcher expectation bias;
participant expectation bias;
inadequate double blinding;
lead-time bias;
selection and sampling bias;
attrition bias; and
early termination.
Contacts were not traced so we don't even know which if any of the men  got HIV from women or even by sex

Wawer et al. (Lancet 374:9685, 229-37) started to find that circumcising men INcreases the risk to women (who are already at greater risk), but they cut that one short for no good reason (nothing they could then do or not do would prevent any new infections) before it could be confirmed.</description>
		<content:encoded><![CDATA[<p>This pile of material reminds me of the TranAmerica building standing upside down. It all rests on the tiny point of  73 out of 5,400 circumcised men who didn&#8217;t get HIV in less than two years, who MIGHT have if they hadn&#8217;t been circumcised, while 64 circumcised men DID get it. </p>
<p>A new review in the Australian Journal of Law and Medicine unravels some of the many reasons that may not be cause and effect:<br />
researcher expectation bias;<br />
participant expectation bias;<br />
inadequate double blinding;<br />
lead-time bias;<br />
selection and sampling bias;<br />
attrition bias; and<br />
early termination.<br />
Contacts were not traced so we don&#8217;t even know which if any of the men  got HIV from women or even by sex</p>
<p>Wawer et al. (Lancet 374:9685, 229-37) started to find that circumcising men INcreases the risk to women (who are already at greater risk), but they cut that one short for no good reason (nothing they could then do or not do would prevent any new infections) before it could be confirmed.</p>
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		<title>Comment on Voluntary Medical Male Circumcision (VMMC) – a cost-effective HIV prevention measure in eastern and southern Africa: a UNAIDS and PEPFAR collection by Roland Day</title>
		<link>http://feeds.plos.org/~r/plos/blogs/plosComments/~3/qU-Zuq9FJrI/</link>
		<dc:creator>Roland Day</dc:creator>
		<pubDate>Fri, 09 Dec 2011 14:25:58 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.plos.org/plos/?p=2773#comment-3241</guid>
		<description>The use of male circumcision to prevent HIV infection is based on three discredited randomised clinical trials. The trials purported to show a 60 percent reduction in female-to-male HIV transmission if the male was circumcised, however the percentage was incorrectly calculated. The correct percentage is 1.3 percent, which falls below statistical significance. 

This tiny reduction is completely overbalanced by a 61 percent INCREASE in male-to-female HIV transmission if the male partner is circumcised.

The premise on which these papers are based - that male circumcision reduces HIV infection  - is false and the papers draw false conclusions.</description>
		<content:encoded><![CDATA[<p>The use of male circumcision to prevent HIV infection is based on three discredited randomised clinical trials. The trials purported to show a 60 percent reduction in female-to-male HIV transmission if the male was circumcised, however the percentage was incorrectly calculated. The correct percentage is 1.3 percent, which falls below statistical significance. </p>
<p>This tiny reduction is completely overbalanced by a 61 percent INCREASE in male-to-female HIV transmission if the male partner is circumcised.</p>
<p>The premise on which these papers are based &#8211; that male circumcision reduces HIV infection  &#8211; is false and the papers draw false conclusions.</p>
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		<title>Comment on Voluntary Medical Male Circumcision (VMMC) – a cost-effective HIV prevention measure in eastern and southern Africa: a UNAIDS and PEPFAR collection by Gregory J. Boyle, PhD (Delaware), PhD (Melbourne), DSc (Queensland)</title>
		<link>http://feeds.plos.org/~r/plos/blogs/plosComments/~3/pPfUKqyKQ_s/</link>
		<dc:creator>Gregory J. Boyle, PhD (Delaware), PhD (Melbourne), DSc (Queensland)</dc:creator>
		<pubDate>Fri, 09 Dec 2011 04:30:16 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.plos.org/plos/?p=2773#comment-3235</guid>
		<description>The Journal of Law and Medicine has published a new critique of those three randomized clinical trials from Africa that have purported to find that male circumcision reduces female-to-male sexual transmission of HIV by 60 percent. This critique finds numerous flaws in the execution of these studies and finds that the actual reduction in HIV transmission is about 1.3 percent, not the claimed 60 percent. The 1.3 percent is not considered to be clinically significant. This is balanced by a 61 percent relative increase in male to female HIV transmission when the male partner is circumcised. Given this, the three RCTs should not be used in the formulation of public health policy. See:

Boyle GJ, Hill G. Sub-Saharan African randomised clinical trials into male circumcision and HIV transmission: Methodological, ethical and legal concerns. J Law Med 2011;19:316-34.</description>
		<content:encoded><![CDATA[<p>The Journal of Law and Medicine has published a new critique of those three randomized clinical trials from Africa that have purported to find that male circumcision reduces female-to-male sexual transmission of HIV by 60 percent. This critique finds numerous flaws in the execution of these studies and finds that the actual reduction in HIV transmission is about 1.3 percent, not the claimed 60 percent. The 1.3 percent is not considered to be clinically significant. This is balanced by a 61 percent relative increase in male to female HIV transmission when the male partner is circumcised. Given this, the three RCTs should not be used in the formulation of public health policy. See:</p>
<p>Boyle GJ, Hill G. Sub-Saharan African randomised clinical trials into male circumcision and HIV transmission: Methodological, ethical and legal concerns. J Law Med 2011;19:316-34.</p>
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		<title>Comment on Voluntary Medical Male Circumcision (VMMC) – a cost-effective HIV prevention measure in eastern and southern Africa: a UNAIDS and PEPFAR collection by John Leonard</title>
		<link>http://feeds.plos.org/~r/plos/blogs/plosComments/~3/Gh7luHSoiH8/</link>
		<dc:creator>John Leonard</dc:creator>
		<pubDate>Thu, 08 Dec 2011 00:16:36 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.plos.org/plos/?p=2773#comment-3227</guid>
		<description>This campaign, and any study involving circumcision, should not get past any ethics committees, if those committees are actually enforcing medical ethics.

It is completely unethical in medicine or public health to base any investigation on the premise of mutilation. Whatever the alleged benefits, they cannot outweigh the fact that circumcision is a harmful procedure.

"First, do no harm."</description>
		<content:encoded><![CDATA[<p>This campaign, and any study involving circumcision, should not get past any ethics committees, if those committees are actually enforcing medical ethics.</p>
<p>It is completely unethical in medicine or public health to base any investigation on the premise of mutilation. Whatever the alleged benefits, they cannot outweigh the fact that circumcision is a harmful procedure.</p>
<p>&#8220;First, do no harm.&#8221;</p>
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		<title>Comment on Voluntary Medical Male Circumcision (VMMC) – a cost-effective HIV prevention measure in eastern and southern Africa: a UNAIDS and PEPFAR collection by Roland Day</title>
		<link>http://feeds.plos.org/~r/plos/blogs/plosComments/~3/-qXJ28DD_gg/</link>
		<dc:creator>Roland Day</dc:creator>
		<pubDate>Fri, 02 Dec 2011 12:39:43 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.plos.org/plos/?p=2773#comment-3193</guid>
		<description>The three RCTs that purport to show that circumcision reduces transmission of HIV were all terminated early. Early termination of studies has been proven over and over again to exaggerate the effect of the intervention. These three RCTs are irremediable flawed, so they should &lt;i&gt;not&lt;/i&gt; be used to guide public health policy.</description>
		<content:encoded><![CDATA[<p>The three RCTs that purport to show that circumcision reduces transmission of HIV were all terminated early. Early termination of studies has been proven over and over again to exaggerate the effect of the intervention. These three RCTs are irremediable flawed, so they should <i>not</i> be used to guide public health policy.</p>
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	<feedburner:origLink>http://blogs.plos.org/plos/2011/11/voluntary-medical-male-circumcision-vmmc-%e2%80%93-a-cost-effective-hiv-prevention-measure-in-eastern-and-southern-africa-a-unaids-and-pepfar-collection/#comment-3193</feedburner:origLink></item>
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